Milestones of C.R.I., Kasauli
| 1906 | Serum for treatment of snake bite and vaccine development for typhoid fever |
| 1911 | Development of neural tissue Rabies vaccine by Sir David Semple. |
| Establishment of Central Malaria Bureau. Development of neural tissue rabies vaccine (Semple vaccine) | |
| 1912 | Establishment of Headquarters of the Indian Research Fund Association (A forerunner of the Present ICMR) |
| 1913 | Establishment of ICMR Library |
| 1914 | Production of Anti Cholera vaccine |
| 1924 | Appointment of Director as the Editor of Indian Journal of Medical Research |
| 1938 | Establishment of Malaria Institute at Delhi and major works connected with malaria transferred. |
| 1939 | Merger of Pasteur Institute of India, Kasauli along with Drumbar Estate with CRI. |
| 1948 | Establishment of Microfilm and photocopying Unit of ICMR. |
| 1953 | Training courses for Diagnosis, prevention and Treatment of Rabies was started. |
| Production of Diphtheria Antitoxin (DAT) | |
| 1954 | Production of Tetanus Antitoxin (TAT) |
| 1955 | Production of Antirabic serum |
| Establishment of Independent Section of Biological Standardization and Quality Control Section. | |
| 1958 | Establishment of National Salmonella and Escherichia Centre and National Collection of Type Cultures. |
| Establishment of Yellow Fever Vaccine Production. | |
| Establishment of Influenza Unit | |
| 1959 | Recognition for M.D., Ph.D. in Microbiology affiliated to Punjab University |
| 1959-60 | Cost Accounting on commercial lines for different products was started. |
| 1961 | Establishment of Triple Vaccine Division. |
| B.Sc. (Hons.) course in Microbiology affiliated to Punjab University was started. | |
| Indian Journal of Medical Research work was shifted to Delhi. | |
| 1966 | Production of AKD Typhoid vaccine. |
| 1972 | Production of BPL Inactivated Antirabic Vaccine |
| 1973 | B.Sc. & M.Sc. courses in Microbiology Affiliated to Himachal Pradesh University were started. |
| 1974 | Establishment of SPF Animal Breeding House. |
| Transfer of ICMR Library to Delhi | |
| 1976 | Lady Linlithgow Sanitarium Estate was taken over for establishment of Research and Training Wing. |
| Training course for Drugs Control Officers was restarted. | |
| 1977 | Establishment of Measles Unit. |
| Recognition of Influenza Unit by WHO as National Influenza Centre. | |
| 1978 | Installation of Fermentors and other sophisticated equipments for large scale production of DTP group of vaccines |
| 1979 | M. Phil. course in Microbiology Affiliated to Himachal Pradesh University was started. |
| Transfer of Polio Vaccine Testing laboratory from NICD, Delhi to CRI, Kasauli. | |
| 1980 | First National Vaccine Course was organized |
| 1982 | Indo-Japanese Collaborative Project for production of Japanese Encephalitis Vaccine was started. |
| 1983 | First National course on quality control of vaccines and sera was organized. |
| 1987 | Recognized as WHO Collaborating Centre for Training and Testing for vaccines used in EPI Programme. |
| Release of first batch of JE Vaccine for volunteers. | |
| Supply of Japanese Encephalitis Vaccines to Assam, West Bengal, U.P. and A.P. under supervision. | |
| 2005 | Independent status of Central Drugs Laboratory |
| 2006 | C.R.I. Centenary celebration |
| 2007 | First time to meet the targets in time for DTP group of vaccines for UIP |
| Initiation of Vero cell based J.E. Vaccine | |
| Expansion of Influenza Surveillance Centre | |
| Expansion of Antisera Division shifted to R&T Wing | |
| Expansion & upgradation of Central Drugs Laboratory. | |
| Recognition of CDL as a WHO Global Training Network Centre | |
| 2008 | The production license of CRI was suspended on 15 Jan, 2008 |
| Ph.D. in Microbiology affiliated to H.P. University was revived and scientists registered. | |
| An additional Library at R&T Wing was established. | |
| 2009 | |
| Creation of New R&D section in the erstwhile ARV Block. | |
| Establishment of New Experimental Animal House for CDL | |
| Renovation of Administrative Block provided with Modern Office Gadgets and computers. | |
| A new canteen was opened in R&T Wing. | |
| Creation of Equine Clinical Laboratory. | |
| Renewal of license for diagnostic reagents. | |
| 2010 | Sanction for the renovation of cGMP compliant DPT production facilities. |
| Visit of Hon’ble Union Minister for Health and Family Welfare, in connection with new cGMP facilities at CRI. | |
| Hosted the 10th IAVI conference. | |
| Revocation of suspension of Vaccine Manufacturing License of the Institute which was under suspension w.e.f. January, 2008. | |
| Accreditation of CDL by NABL. | |
| April 2010 To March 2011. |
The Treatment Centre was expanded to accommodate three beds, a minor OT, separate room for the Traction machine and the Clinical Laboratory is expanded to accommodate the increase load of testing. |
| The central Instrumentation and Analytical Laboratory gains NABL accreditation on the 28th of the June 2010 for the period of one and half years. | |
| Renovation of cGMP compliant facility for the production of DTP group of vaccine was finally realized in the month of May, 2010 and work commenced. | |
| Procurement of various equipments and machinery that are essential in ensuring cGMP compliance was initiated | |
| Training of staff which forms a vital link in ensuring compliance was also addressed during the year. | |
| April 2011 To March 2012 |
Renovation and up-gradation of cGMP compliant DTP facility is in the final stage of completion. |
| All major equipments and machinery are installed and OQ was in progress. | |
| Treatment centre was equipped with Short-wave diathermy and Oxygen concentrated. | |
| CRI vaccines were labeled with VVM for the first time | |
| Acetone killed freeze dried typhoid (AKD) vaccine production stopped. | |
| QA division shifted in AKD block. | |
| April 2012 To March 2013 |
cGMP compliant DTP facility completed. |
| Joint Inspection was held on 16th & 17th Dec., 2012 for approval of New DTP Vaccine block and permission for consistency & commercial batches was granted by the DCGI. | |
| A new VIP guest house block completed in main CRI campus. | |
| Work on the rain water harvesting tank in main CRI campus started by IPH Deptt. of H.P. | |
| April 2013 To March 2014 |
Trial runs for production of DTP group of vaccines have been successfully completed. |
| April 2014 To March 2015 |
CRI is recognized as Centre of Excellence for Teaching and Training in Microbiology by Himachal Pradesh University. |
| Steps initiated for production of consistency batches in the new DPT facility. | |
| April 2016 To March 2017 |
The new GMP compliant DPT facility was inaugurated on 24th April. 2016 |
| First ever website of the institute designed and launched (www.crikasauli.nic.in) | |
| Six commercial batches of Tetanus Toxoid vaccine (adsorbed) IP manufactured at the new cGMP facility | |
| Institute started skill-development one-year certificate course in Production of Immurenobiologicals& Animal Care?, affiliated to the State Council of Vocational Training, Himachal Pradesh with registration of 25 candidates. | |
| National workshop and serotyping of Salmonella and Escherichiacoli was conducted successfully with participation of 32 participants from all over the country as well as internal students. | |
| MoU has been signed with HPU, Shimla for research. | |
| Biometric attendance System (AE-BAS)implemented and executed successfully. | |
| April 2017 To March 2018 |
Process of introduction of Td vaccine in existing product portfolio initiated. We have obtained test license from DCGI for manufacturing of Td vaccine for test and analysis purpose. |
| The first batch of the one-year certificate course in Production of Immunobiologicals& Animal Care?, affiliated to SCVT, H.P. passes out and the strength of the candidates enhanced from 25 to 50 candidates. | |
| Polio testing laboratory awarded with the highest-grade in WHO inspection. | |
| Implementation of Pharmacovigilance program at CRI. | |
| CRI been recognized as Surveillance centre for Zika virus infection in humans, India. | |
| April 2018 To March 2019 |
Establishment of independent pharmacovigilance division at CRI. |
| Waiver obtained for animal toxicological studies and clinical trials for Td vaccine. | |
| NOC Obtained for Post Approval Change for the manufacturing of Diphtheria toxoid bulk, Inactivated Bordetella Pertussis bulk antigens and TT vaccine. | |
| April 2019 To March 2020 |
The Institute has initiated the Commercial manufacturing and supply of the DPT vaccine to UIP from new cGMP facility. |
| April 2020 To March 2021 |
Establishment of ICMR approved COVID testing Laboratory at CRI. |
| The Institute has initiated the development of therapeutic antisera for COVID-19 in collaboration with ICMR-NIV. |
